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KMID : 0613820060160050746
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Journal of Life Science
2006 Volume.16 No. 5 p.746 ~ p.749
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Cytotoxic Flavonoids from the Whole Plants of Chrysanthemum zawadskii Herbich var. latilobum Kitamura
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Kwon Hyun-Sook
Yang Min-Suk
Ha Tae-Joung
Hwang Seon-Woo
Jin Young-Min
Nam Sang-Hae
Park Ki-Hoon
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Abstract
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Two known flavonoids, luteolin (1) and acacetin (2) were isolated from a CHCl₃ soluble fraction of the whole plants of Chrysanthemum zawadskii Herbich var. latilobum Kitamura, and their structures were determined by NMR analysis. The luteolin (1) was isolated from this plant for the first time. These compounds were examined for their in vitro cytotoxic activities against four human cancer cell lines including HCT116 (colon), UO-31 (renal), PC-3 (prostate) and A549 (lung) by sulforhodamine B(SRB) assay. Acacetin (2) showed significant cytotoxic activity against HCT116 and UO-31 cells with an IC?? of 2.44 and 2.89 μg/ ml, respectively.
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KEYWORD
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Chrysanthemum zawadskii Herbich var, latilobum Kitamura, luteolin, acacetin, sulforhodamine B, cytotoxic activity
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